Dangerous threats keep Michael and Lincoln fighting to protect Sara and Mike; Poseidon's attempts to outsmart Michael and the rest of the gang lead them to the ultimate showdown.
When Sara and her son are threatened, Michael and Lincoln recruit the help of Sheba and C-Note to catch Poseidon; Whip sets out on a separate mission; T-Bag reveals a secret.
Sara becomes fearful of her family's safety when she discovers the real reason that Michael faked his own death. In the meantime, Michael and Lincoln continue to try find a way home with the help of Sucre, and the real identity of Poseidon is revealed.
As Michael, Lincoln and the remaining Ogygia gang try to escape Yemen, they find themselves racing though the desert from a vengeful Cyclops. Meanwhile, A&W and Van Gogh question their roles as their pursuit of the escapees leads them to...Graceland.
Lincoln becomes frustrated as he tries to understand what really happened to Michael. C-Note has a new escape plan, but fears it will not be executed quickly enough, as Cyclops is trailing closely behind. Meanwhile, Sara struggles with the idea that Michael may be alive.
season 1 of Prison Break contains a total of 22 episodes which were originally broadcast in the United States from August 29, 2005 to May 15, 2006. The plot revolves around the plan of Michael Scofield to break his brother, Lincoln Burrows, out of prison. It covers approximately six weeks of the characters' lives (from April 11th to May 27th) - the entire length of Michael's stay at Fox River State Penitentiary. An average of 9.2 million viewers was recorded for the season.
Lincoln Burrows (Dominic Purcell) is accused of the murder of Terrence Steadman, who is the brother of the female Vice President of the United States. With strong evidence supporting the charges of first degree murder and aggravated discharge of a firearm against him, Lincoln is sentenced to death and is sent to Fox River State Penitentiary to await his execution. Lincoln's brother, Michael Scofield (Wentworth Miller), is convinced of Lincoln's innocence and hatches an escape plan. After installing himself at Fox River, time works against Michael as he must overcome various obstacles and make the right connections among the inmates and prison staff to be successful in breaking out his brother.The Brothers are aided by Veronica Donovan (Robin Tunney), who begins to investigate the conspiracy that put Lincoln in jail. However, they are hindered by covert agents, who belong to an organization known as 'The Company'. As the season goes on Michael is successful in recruiting other inmates into his escape plan. When the season comes to and end The Brothers and the other inmates break out of Fox River.